Most fantasy football owners — at least the ones still alive in their playoffs — are aware of the ridiculous amount of players that have been on and off of the reserve/COVID-19 list in the past week, and it’s likely we’ll have to continue dealing with that going forward. As such, it’s important to become very familiar with our Week 16 fantasy WR PPR rankings, as you never know who will wind up inactive when game day rolls around. Hopefully, the worst is past us, but either way, you’ll still have to make some tough start ’em, sit ’em decisions in this must-win week.

A.J. Brown (vs. 49ers) and Antonio Brown (@ Panthers) are eligible to return this week, and there’s little doubt many fantasy owners are patiently waiting to insert one of the Browns back into their lineups. Neither have particularly favorable matchups, but as long as they’re active, they should both be starting for fantasy owners.

Quarterback | Running back | Tight end | D/ST | Kicker

Mike Evans and Chris Godwin (vs. 49ers) are too good to sit despite the same tough matchup Antonio is facing. (Update: Godwin is out for the rest of the season and Evans is week-to-week with a hamstring injury.) The same goes for Stefon Diggs (@ Patriots). Brandin Cooks (vs. Chargers) is a boom-or-bust option, but he’s actually played better with Davis Mills, so you can still take your chances with him if you’re looking for a high ceiling.

Quarterback | Running back | Wide receiver | Tight end | D/ST | Kicker

Jamison Crowder (vs. Jaguars), Amon-Ra St. Brown (@ Falcons), and Russell Gage (vs. Lions) look to be the best PPR plays among players less than 51-percent owned in Yahoo leagues. In deeper leagues, Braxton Berrios (vs. Jaguars) and Josh Reynolds (@ Falcons) can be considered, too. The loss of T.J. Hockenson, Elijah Moore, and Corey Davis has opened the door for more opportunities among Lions’ and Jets’ pass-catchers, and in matchups as glorious as these, we’re fairly confident they will deliver.

WEEK 16 FANTASY: Sleepers | Busts | Start ’em, sit ’em

Boom-or-bust players are more attractive in standard leagues, but at some point in the rankings, you have to consider them in PPR, too. Players in that group include Marquez Callaway and Tre’Quan Smith (vs. Dolphins), Marvin Jones and Laquon Treadwell (@ Jets), Robby Anderson (vs. Buccaneers), and Marquez Valdes-Scantling and Allen Lazard (vs. Browns). All but the Packers have solid matchups, but at this point, those WRs can boom or bust in any matchup when tied to Aaron Rodgers.

WEEK 16 DFS LINEUPS: DraftKings | FanDuel | Yahoo

Jerry Jeudy (@ Raiders), Gabriel Davis and Cole Beasley (@ Patriots), Kenny Golladay and Kadarius Toney (@ Eagles), Rashod Bateman (@ Bengals), T.Y. Hilton (@ Cardinals), and K.J. Osborn (@ Rams) are in rocky matchups, and since we haven’t been able to count on them with any sort of consistency, it’s possible — even likely — you have better options. You can actually extend that to Michael Pittman (@ Cardinals), Marquise Brown (@ Bengals), and possibly Adam Thielen (@ Rams) if he returns, as all have either struggled or been dinged up lately. Brown has a high PPR floor, though, so he’s the safest of that group.

MORE WEEK 16 DFS: Best stacks | Lineup Builder

At this point in the season, you have to be aware of non-contending teams taking it easy with dinged-up players, as well as the obvious COVID worries. Have backups ready — then have backups for your backups — and when in doubt, trust the matchups. 

Note: We’ll be updating these WR PPR rankings as needed throughout the week, so check back for the latest changes and analysis. For individual analysis of key WRs, click here.

​Fantasy WR PPR Rankings Week 16: Who to start at wide receiver

Rankings based on full-point PPR scoring

1Cooper Kupp, LAR @ MIN
2Davante Adams, GB vs. CLE
3Tyreek Hill, KC vs. PIT
4Keenan Allen, LAC @ HOU
5Deebo Samuel, SF @ TEN
6Justin Jefferson, MIN vs. LAR
7Jaylen Waddle, MIA @ NO
8CeeDee Lamb, DAL vs. WAS
9Tyler Lockett, SEA vs. CHI
10Diontae Johnson, PIT @ KC
11Terry McLaurin, WAS @ DAL
12Antonio Brown, TB @ CAR
13Amari Cooper, DAL vs. WAS
14Stefon Diggs, BUF @ NE
15DeVonta Smith, PHI vs. NYG
16Ja’Marr Chase, CIN vs. BAL
17Tee Higgins, CIN vs. BAL
18DK Metcalf, SEA vs. CHI
19Brandon Aiyuk, SF @ TEN
20D.J. Moore, CAR vs. TB
21Odell Beckham Jr., LAR @ MIN
22A.J. Green, ARI vs. IND
23Van Jefferson, LAR @ MIN
24A.J. Brown, TEN vs. SF
25Darnell Mooney, CHI @ SEA
26Hunter Renfrow, LV vs. DEN
27Russell Gage, ATL vs. DET
28DeVante Parker, MIA @ NO
29Adam Thielen, MIN vs. LAR
30Christian Kirk, ARI vs. IND
31Julio Jones, TEN vs. SF
32Jarvis Landry, CLE @ GB
33Emmanuel Sanders, BUF @ NE
34Chase Claypool, PIT @ KC
35Michael Gallup, DAL vs. WAS
36Michael Pittman Jr., IND @ ARI
37Kendrick Bourne, NE vs. BUF
38Jerry Jeudy, DEN @ LV
39Tyler Johnson, TB @ CAR
40Jakobi Meyers, NE vs. BUF
41Robby Anderson, CAR vs. TB
42Donovan Peoples-Jones, CLE @ GB
43Allen Lazard, GB vs. CLE
44Kenny Golladay, NYG @ PHI
45Amon-Ra St. Brown, DET @ ATL
46Marquise Brown, BAL @ CIN
47Josh Palmer, LAC @ HOU
48Tre’Quan Smith, NO vs. MIA
49Marquez Callaway, NO vs. MIA
50Laquon Treadwell, JAX @ NYJ
51Marvin Jones, JAX @ NYJ
52Braxton Berrios, NYJ vs. JAX
53K.J. Osborn, MIN vs. LAR
54Josh Reynolds, DET @ ATL
55Rashod Bateman, BAL @ CIN
56Curtis Samuel, WAS @ DAL
57Tyler Boyd, CIN vs. BAL
58Courtland Sutton, DEN @ LV
59Mecole Hardman, KC vs. PIT
60Nico Collins, HOU vs. LAC
61Nick Westbrook-Ikhine, TEN vs. SF
62Lil’Jordan Humphrey, NO vs. MIA
63Kalif Raymond, DET @ ATL
64Keelan Cole, NYJ vs. JAX
65T.Y. Hilton, IND @ ARI
66DeSean Jackson, LV vs. DEN
67Antoine Wesley, ARI vs. IND
68James Washington, PIT @ KC
69DeAndre Carter, WAS @ DAL
70Tim Patrick, DEN @ LV
71Chester Rogers, TEN vs. SF
72Zach Pascal, IND @ ARI
73Dee Eskridge, SEA vs. CHI
74Jauan Jennings, SF @ TEN
75Bryan Edwards, LV vs. DEN
76Zay Jones, LV vs. DEN
77Darius Slayton, NYG @ PHI
78Isaiah McKenzie, BUF @ NE